Top Labs To Run Bi-Annually On Your Peptic Ulcer Disease Patients

If your patients take antacids like they’re going out of style, or if they tell you that they are constantly grazing in between meals because it helps with their stomach pain or heartburn, then this article may be helpful. One in ten people will develop peptic ulcers. This condition can cause some of the previously mentioned behaviors to manage the digestive issues that can occur because of ulcers. Though ulcers may sometimes heal by themselves, this can be a forewarning sign as ulcers can lead to serious health issues. However, with proper testing, you can help get to your patient’s underlying cause(s) of their ulcers to help effectively treat them.

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What is Peptic Ulcer Disease?

Peptic ulcer disease (PUD) refers to painful sores or ulcers in the stomach (gastric ulcers) or a part of the small intestine (duodenal ulcers) caused by erosion of the lining that is usually protecting this area. The digestive lining is typically protected by a thick layer of mucus that can shield it from stomach acid. However, this layer can be disrupted and lead to ulcerations.

What Causes Peptic Ulcer Disease? 

There are several causes of PUD. These include H. Pylori, medications such as NSAIDs, tobacco or alcohol use, genetics, and other conditions. Many people develop PUD because of the overgrowth of Helicobacter pylori (H. pylori) bacteria. In fact, this is the most common cause, with 90% found in duodenal ulcers and 70% found in gastric ulcers. 

People who take pain relievers such as NSAIDs are also more likely to develop ulcers which is the second most common cause of PUD. Regularly using NSAIDs can suppress the intestine's defenses, leading to inflammation that breaks down the lining. Other medications that can increase the risk include steroids, anticoagulants, SSRI antidepressants, and bisphosphonates. 

Genetics has also been associated with PUD as it tends to run in families. Although less common, other conditions include Zollinger-Ellison syndrome (condition of excess stomach acid), cancer, Crohn's disease, celiac disease, and infections like Epstein-Barr virus (EBV) and Candida albicans can lead to ulcers. 

Lifestyle factors also play a part in developing ulcers, such as smoking or alcohol use, reducing mucus production, and increasing stomach acid. While stress and spicy foods are not proven to cause ulcers, they can worsen existing ulcers and slow the healing process.

Peptic Ulcer Disease Symptoms

It's important to note that not everyone with ulcers experiences symptoms. However, ulcers can present with the following symptoms:

• Lingering or burning stomach pain between meals or in the evening
• Relieved pain after food or taking an antacid
• Abdominal distension
• Heartburn
• Nausea

Symptoms that may be red flags include:

• Vomiting
• Black stools
• Weight loss
• Pain that is severe

What Are The Benefits of Regular Lab Testing For Patients With Peptic Ulcer Disease?

Not everyone experiences symptoms even though they have ulcers. Therefore, it's vital for individuals who are at risk to get tested, as ulcerations can lead to serious health issues without treatment, such as perforation, gastric outlet obstruction, or bleeding. However, with those who are experiencing symptoms, it is recommended that retesting be completed regularly to determine if the treatment was sufficient or if any adjustments need to be made. Functional medicine labs also provide insight into the underlying factors causing ulcers so treatments can be personalized, often resulting in better health outcomes.

Top Labs To Run Bi-Annually On Patients With Peptic Ulcer Disease

The top labs used by functional medicine clinicians to help their patients with PUD are the following:

H. Pylori Testing

H. Pylori is the bacteria that cause PUD and is the primary reason for its development. This bacteria has been shown to cause the protective layer of the digestive tract to break down, allowing stomach acid to create ulcerations. This H. Pylori stool test measures the bacteria and antibiotic-resistant genes, which allows for more precise guidance in treatment protocols for practitioners. This test can be a powerful tool to help monitor H. Pylori levels after treatment and to help with decreasing the risk of PUD and improving existing ulcers.

Gut Zoomer

The gut zoomer measures various pathogens in the gastrointestinal tract that can lead to chronic disease. Disruptions in the gut microbiome due to the overgrowth of these microbes can indicate conditions such as Crohn's (a form of IBD), candida overgrowth, or celiac, all of which are implicated as a possible cause of PUD. The results of this stool test can help clinicians investigate underlying causes of PUD for their patients, and retesting after treatment protocols can help monitor the effectiveness of treatments.

Cortisol Stress Test

Cortisol is a key stress hormone produced by the body. In appropriate amounts, it is vital and beneficial. Yet, excessive and prolonged cortisol levels can be harmful. Cortisol release follows our circadian rhythm, but chronic stress can disrupt this pattern, leading to health issues. By testing cortisol levels throughout the day, we can understand its production and timing. Although stress hasn't been indicated to cause ulcers, it can exasperate its symptoms. Thus, regular monitoring of stress levels through this saliva test is recommended to help balance stress levels and reduce the severity of symptoms in PUD patients.

Additional Labs to Check 

An upper endoscopy is the standard to confirm the diagnosis of PUD. Although less common, other imaging tests such as CT scans and X-rays may also be used to determine the occurrence of ulcerations after drinking a special liquid that makes the ulcers more visible on imaging. These should be ruled out if other conditions are suspected of causing PUD. Conditions like EBV infection can be tested by an antibody serum test or Zollinger Ellison by fasting serum gastrin levels. These conditions are rare causes of ulcers but should still be ruled out.

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Summary

PUD can be asymptomatic in some people but can cause lingering pain in others. If your patients have symptoms or not, they should still get tested regularly to assess for ulcers if you suspect they are at risk for them or have a history of PUD. If left untreated, these ulcerations can lead to more serious issues, including cancer in more severe cases. Not to worry, though. Functional medicine labs can be completed easily, helping you to address your patient’s underlying root causes that may be increasing their risk of ulcers while providing guidance on how to individualize treatment protocols to help effectively manage PUD.