The TruAge Complete Collection offers a suite of epigenetic aging reports and algorithms to provide a comprehensive picture of biological aging. While chronological age may dictate the passing of time, biological age provides a deeper insight into an individual's overall health status and susceptibility to age-related diseases.
The TruAge Complete Collection includes Dunedin PACE, the only publicly available aging algorithm trained on phenotypes and variables of health rather than chronological age. It now also includes the most advanced and predictive aging algorithm ever created, OMICm Age, developed by TruDiagnostic in partnership with Harvard University. OMICm Age provides novel insights into the reasons why someone is experiencing advanced aging.
In addition to this information, the TruAge Complete Collection also provides insights into other age-related factors including a person’s blood sugar and inflammation regulation status, fitness age, their weight loss response, and more.
Biological age encapsulates the physiological state of an individual's body, reflecting the cumulative impact of lifestyle, genetics, and environmental factors on aging processes. Unlike chronological age, which remains constant, biological age can vary significantly among individuals of the same age group. [2., 9.] This discrepancy underscores the importance of personalized age assessment to tailor interventions and mitigate age-related health risks effectively.
Assessing biological age involves a multifaceted approach encompassing various biomarkers that collectively reflect the physiological state of an individual's body and the processes underlying aging. Telomere length, one such biomarker, is indicative of cellular aging and overall health. Telomeres, the protective caps at the ends of chromosomes, undergo progressive shortening with each cell division. Studies have demonstrated a correlation between shortened telomeres and accelerated aging, as well as an increased risk of age-related diseases. A number of lifestyle factors may be responsible for telomere shortening. [4., 5.]
Assessing immune health and inflammation status also reveals information about a person’s biological age. Immune health, often assessed through the CD4/CD8 T cell ratio, plays a crucial role in determining biological age. [11.]
Inflammation, as measured by markers such as C-reactive protein (CRP) and interleukin-6 (IL-6), is another key biomarker for biological age. Chronic low-grade inflammation, or inflammaging, is implicated in various age-related diseases. [6.]
DNA methylation patterns, reflecting epigenetic modifications, are also informative biomarkers for biological age. Changes in DNA methylation status are associated with aging and age-related diseases, and increasingly show potential in age-related health assessment. [7.]
These biomarkers, along with others such as oxidative stress markers and metabolic parameters, collectively provide a comprehensive assessment of biological age, enabling personalized interventions aimed at promoting healthy aging and enhancing overall well-being.
The TruAge Complete Collection comprises a suite of diagnostic assays designed to evaluate various biomarkers associated with aging processes. Each component of the collection offers insights into different facets of biological age, empowering individuals to take proactive measures towards optimal health and longevity.
The OMICm Age Report, developed in collaboration with Harvard University, forms an integral component of the TruAge Complete Lab Test. The OMICm Age Report leverages omics technologies to provide individuals with comprehensive insights into their biological age and personalized recommendations for optimizing healthspan. By analyzing multiomic data, including genomics, transcriptomics, proteomics, and metabolomics, the OMICm Age Report offers a holistic assessment of aging processes at the molecular level, empowering individuals to take proactive measures towards enhancing their overall well-being and longevity. [3., 8.]
At the heart of the DunedinPACE Report lies the Dunedin Study, a longitudinal research endeavor that has significantly contributed to our understanding of aging processes and their impact on health outcomes. Initiated in 1972 in Dunedin, New Zealand, the ongoing Dunedin Study has followed a cohort of over 1,000 individuals from birth to adulthood, meticulously documenting various aspects of their physical health, psychological well-being, and social functioning. [10.]
The Pace of Aging report uses the DunedinPACE algorithm to calculate current speed of aging.
Other reports included as part of the TruAge Complete Collection include:
Immune Report
Telomere Length Report
Type 2 Diabetes Risk Report
Inflammation Report
Mitotic Clock Report
Fitness Age Report
Smoking and Drinking Report
Weight Loss Response Report
Extrinsic and Intrinsic Age Report
Together, these provide a comprehensive understanding of an individual’s biological age, in comparison to their chronological age.
The TruAge Complete Collection by TruDiagnostic is recommended for individuals who are interested in gaining a comprehensive understanding of their biological age and overall health status. This test is particularly beneficial for:
Individuals interested in optimizing their healthspan and longevity: The TruAge Complete Collection sheds insights into various aspects of biological aging, empowering individuals to adopt proactive measures to promote healthy aging and enhance overall well-being.
Those concerned about age-related health risks: By assessing biomarkers associated with aging processes, such as telomere length, epigenetic markers, and physiological parameters, the TruAge Complete Collection enables individuals to identify potential health risks and implement targeted interventions to mitigate them.
Individuals seeking personalized health recommendations: Based on the findings of the age assessment and health risk profiling, the TruAge Complete Collection generates personalized health recommendations tailored to individual needs and preferences, guiding individuals towards lifestyle modifications, dietary interventions, and preventive healthcare measures.
Individuals with a personal or family history of cardiometabolic disease or cognitive decline: These individuals may benefit from undergoing the TruAge Complete Collection test by TruDiagnostic. Given the comprehensive nature of this test, it can provide valuable insights into various biomarkers associated with aging and age-related health risks, including those related to cardiometabolic health and cognitive function. [1., 3.]
Healthcare professionals and researchers: The TruAge Complete Collection offers data for healthcare professionals and researchers studying aging processes, age-related diseases, and interventions aimed at promoting healthy aging. By leveraging the insights provided by the TruAge Complete Collection, healthcare professionals can develop personalized treatment plans and researchers can advance our understanding of aging and age-related health outcomes.
Overall, the TruAge Complete Collection is suitable for individuals of all ages who are interested in proactively managing their health, optimizing their aging trajectory, and enhancing their quality of life.
Prepare: Hydrate for 24 hours before collecting your sample. Continue taking medications and supplements as usual.
Registration: Visit www.trudiagnostic.com/register or scan the QR code on your kit to complete online registration.
Collection:
a. Clean a finger with the provided alcohol wipe.
b. Use the lancet to prick your finger and collect drops of blood on the designated circles on the card.
c. Ensure blood saturates the card and air dry for at least 3 hours.
Packaging:
a. Place the dried card into the biohazard bag.
b. Seal the bag and place it in the return envelope.
Shipping: Ship the sample via USPS the same day if possible or refrigerate until shipping.
Results: Results are typically available to your provider 2-3 weeks after the lab receives your sample.
Remember, registration is required for analysis, and ensure prompt shipping of your sample for accurate results.
REFERENCES
[1.] Bell SP, Giuseffi JL, Forman DE. Cardiovascular biomarkers and their utility in the older adult. Curr Cardiovasc Risk Rep. 2012 Oct;6(5):397-403. doi: 10.1007/s12170-012-0262-0. Epub 2012 Jul 28. PMID: 28286599; PMCID: PMC5344197.
[2.] Belsky DW, Caspi A, Houts R, et al. Quantification of biological aging in young adults. Proceedings of the National Academy of Sciences. 2015;112(30):E4104-E4110. doi:https://doi.org/10.1073/pnas.1506264112
[3.] Currais A, Goldberg J, Farrokhi C, Chang M, Prior M, Dargusch R, Daugherty D, Armando A, Quehenberger O, Maher P, Schubert D. A comprehensive multiomics approach toward understanding the relationship between aging and dementia. Aging (Albany NY). 2015 Nov;7(11):937-55. doi: 10.18632/aging.100838. PMID: 26564964; PMCID: PMC4694064.
[4.] Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5. doi: 10.1073/pnas.0407162101. Epub 2004 Dec 1. PMID: 15574496; PMCID: PMC534658.
[5.] Epel ES, Merkin SS, Cawthon R, et al. The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men: a novel demonstration. Aging. 2008;1(1):81-88. doi:https://doi.org/10.18632/aging.100007
[6.] Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007 Jan;128(1):92-105. doi: 10.1016/j.mad.2006.11.016. Epub 2006 Nov 20. PMID: 17116321.
[7.] Horvath S. DNA methylation age of human tissues and cell types. Genome biology. 2013;14(10):R115. doi:https://doi.org/10.1186/gb-2013-14-10-r115
[8.] Johnson LC, Parker K, Aguirre BF, Nemkov TG, D'Alessandro A, Johnson SA, Seals DR, Martens CR. The plasma metabolome as a predictor of biological aging in humans. Geroscience. 2019 Dec;41(6):895-906. doi: 10.1007/s11357-019-00123-w. Epub 2019 Nov 9. PMID: 31707594; PMCID: PMC6925078.
[9.] Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018;10(4):573-591. doi:https://doi.org/10.18632/aging.101414
[10.] Poulton R, Moffitt TE, Silva PA. The Dunedin Multidisciplinary Health and Development Study: overview of the first 40 years, with an eye to the future. Soc Psychiatry Psychiatr Epidemiol. 2015 May;50(5):679-93. doi: 10.1007/s00127-015-1048-8. Epub 2015 Apr 3. PMID: 25835958; PMCID: PMC4412685.
[11.] Wikby A, Strindhall J, Johansson B. The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies. Springer eBooks. Published online January 1, 2009:3-28. doi:https://doi.org/10.1007/978-1-4020-9063-9_1
The TruAge Complete Collection offers a suite of epigenetic aging reports and algorithms to provide a comprehensive picture of biological aging. It includes DunedinPACE, the only publicly available aging algorithm trained on phenotypes and variables of health rather than chronological age. The new OMICmAge created with Harvard is the world's first-ever Biological Age clock powered by clinical lab, metabolomic, and proteomic data. OMICmAge is better at predicting health and aging outcomes than any other methylation age clock to date.
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