SLCO1B1

SLCO1B1

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What's

SLCO1B1

SLCO1B1 is a gene that gives instructions for creating a protein that has an essential function in our body. This protein, called organic anion transporting polypeptide 1B1, is mainly found in the liver. It acts like a security guard, managing the entry of specific substances, such as certain medications and hormones, into liver cells. One of its main tasks is to help move statins - a kind of medicine used to reduce cholesterol - into the liver where they can work effectively. By doing this, it affects how your body reacts to these medications. In short, SLCO1B1 is a critical part of your body's drug processing system, ensuring that medicines are efficiently delivered to where they are needed.

If Your Levels Are High

Having higher than normal levels of SLCO1B1 might mean that your body is really good at moving certain substances, like some medications and hormones, into your liver cells. This could mean that you break down certain drugs, like cholesterol-lowering statins, faster or more effectively than other people. However, it could also mean that you might be more likely to experience side effects from these drugs. Things like your diet, lifestyle, and taking certain medications, such as blood pressure medications or oral contraceptives, could possibly affect how active the SLCO1B1 gene is in your body.

Symptoms of High Levels

Symptoms of high levels of SLCO1B1 are not typically noticeable, as this gene primarily influences how your body processes certain medications and hormones. Any potential symptoms would likely be related to the effects of these substances in your body.

If Your Levels are Low

Having low levels of SLCO1B1 might mean that your body isn't as good at moving certain substances, like some medications and hormones, into your liver cells. This can affect how well your body handles certain drugs, like statins, which help lower cholesterol. Things like your diet, lifestyle, and specific medications could play a role in how active this gene is. Low SLCO1B1 levels could be linked to issues like imbalances in your metabolism or problems with how your liver works.

Symptoms of Low Levels

Symptoms of low levels of SLCO1B1 may not be directly observable, as this gene primarily influences how your body processes certain substances. However, potential indirect signs could include less effective response to certain medications, such as statins, or issues related to liver function.

See References

Test for

3X4 Genetics Test + Blueprint Report

3X4 Genetics

Swab

The 3X4 Genetics Test + Blueprint Report provides 36 key insights and practical, personalized recommendations for patients to start taking control of their health.

PgX (Pharmacogenomic) Test

TruDiagnostic

Swab

The PgX (Pharmacogenomic) Test examines a patient's inherited genes to detect variations that may impact how a drug is broken down, absorbed, and used within the body.

MedCheck

DNAlife

Blood Spot

MedCheck gives insights into a patient's responsiveness to different medications and the likelihood of side effects and treatment failure. It provides insight into how a patient metabolizes, transports, and binds specific drugs, allowing physicians to prescribe medications that are most likely to prove effective with minimal side effects.

Statin-Induced Myopathy (SLCO1B1) Genotype

Boston Heart Diagnostics

Whole Blood

This test detects variations in the SLCO1B1 gene. It identifies individuals with a specific drug transporter defect associated with statin-induced myopathy. It assists healthcare providers in selecting a statin that is less likely to cause this adverse event. Please be advised that Boston Heart Diagnostics policy states that practitioners are unable to order labs on themselves or their immediate family members.

Statin-Induced Myopathy (SLCO1B1) Genotype Add-On

Boston Heart Diagnostics

Whole Blood

This test detects variations in the SLCO1B1 gene. It identifies individuals with a specific drug transporter defect associated with statin-induced myopathy. It assists healthcare providers in selecting a statin that is less likely to cause this adverse event. This test can be added to any other Boston Heart genetics test. Please be advised that Boston Heart Diagnostics policy states that practitioners are unable to order labs on themselves or their immediate family members.

CONTENTS

What is it?

High Levels

Low Levels

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