While estrogen is traditionally thought of as the hormone associated with female physiology, it’s also crucial for male health. Though it can cause problems when present in high amounts in men, estrogen is needed for many body functions. It’s vital to achieve optimal male health and well-being.
This article explores the role of estrogen in men and how to identify hormone imbalances, including estrogen irregularities in males.
[signup]
What is Estrogen?
Estrogen, often called the female hormone, is a chemical messenger needed for optimal physical and cognitive functioning in men and women. Its forms include:
- Estrone (E1): the form of estrogen that women continue to make after menopause. Men’s and women’s bodies both make E1 in the adrenal glands and body fat.
- Estradiol (E2): a main form of estrogen in nonpregnant women of childbearing age. E2 is made in the ovaries of women and plays a vital role in fertility, bone health, and brain health. Men make small amounts of E2 in their testicles.
- Estriol (E3): the form of estrogen that increases during pregnancy. Men and nonpregnant women possess very low levels of E3.
Estrogen Production and Function in Men
Men produce estrogen in their bodies using the aromatase enzyme, which converts testosterone into estrogen and works to provide an ideal testosterone: estrogen ratio.
The functions of estrogen in men include:
- Bone density maintenance
- Musculoskeletal health
- Fat distribution
- Cardiovascular health
- Sex drive
- Erections
- Sperm production
- Fertility
- Central nervous system functioning
- Blood sugar control
- Cholesterol regulation
- Blood flow and circulation maintenance
- Collagen production
- Skin health
- Brain function
- Ability to focus
Maintaining an ideal estrogen level is extremely important for men to achieve optimal hormone balance and maximize their reproductive, mental, physical, and overall health.
Normal Estrogen Levels in Men
Normal estrogen levels in men are as follows:
- Estradiol (E2): 10 to 40 picograms per milliliter (pg/mL)
- Estrone (E1): 10 to 60 picograms per milliliter (pg/mL)
Actual estrogen levels in men vary by age, health conditions, and lifestyle habits.
Patients with levels above or below a desirable range or who exhibit symptoms of estrogen or testosterone imbalance should see a healthcare provider for an evaluation and lab testing.
The Importance of Having Normal Estrogen Levels
Maintaining balanced estrogen optimizes mood, cognitive performance, and sexual wellness in men and women while reducing the risk of medical complications.
Studies show that estrogen balance is vital in men for regulating libido (sex drive), sperm production, and erectile functioning. Estrogen in men also contributes to the normal functioning of healthy cardiovascular, skeletal, and central nervous systems.
Estrogen or testosterone imbalances in men may lead to an array of bothersome symptoms, which can negatively impact their quality of life.
Health Implications of Imbalanced Estrogen Levels
The health implications men may face depend on the type of estrogen imbalance (too high or too low) they struggle with.
High Estrogen Levels in Men
The causes and symptoms of high estrogen levels include:
Causes
- Some medications
- Obesity
- High body fat percentage
- Genetics
- Family history of high estrogen
- Stress
- Hormone therapy
- Excessive amounts of alcohol
- Liver problems
- Tumors that make estrogen
- Synthetic xenoestrogens
Synthetic xenoestrogens are environmental chemicals with estrogen-like properties. Examples include phthalates and bisphenol A (BPA), which are present in some plastics, pesticides, shampoos, soaps, and household cleaning products.
Symptoms
The symptoms of high estrogen in men include:
- Gynecomastia (enlarged breasts)
- Infertility (inability to get a partner pregnant)
- Erectile dysfunction (ED)
Studies show that men with higher levels of estradiol had increases in psychological distress and spontaneous erections.
Low Estrogen Levels in Men
Examples of causes and symptoms of low estrogen in men include:
Causes:
- Autoimmune diseases
- Eating disorders
- Genetic conditions
- Radiation therapy
- Chemotherapy
- Conditions that affect the pituitary gland
- Aging
The cause isn’t always known, and low estrogen may develop because of more than one condition.
Symptoms and health risks
Symptoms of low estrogen in men may include:
- Abdominal fat
- Bone loss
- Osteoporosis
- Reduced sex drive
- Dry skin
- Moodiness
- Irritability
- Trouble concentrating
- Fatigue
- Problems sleeping
Potential health risks associated with low estrogen in men include mood disorders and cardiovascular diseases.
Managing Estrogen Levels in Men
Ways to assess and properly manage estrogen levels in men include:
Diagnosing Estrogen Imbalances
Blood, urine, or saliva estrogen testing can establish a man’s estrogen levels and whether or not he needs treatment for low or high estrogen. There’s no special preparation needed before completing estrogen lab tests.
Providers also discuss the patient’s medical history, review their symptoms, and complete a physical exam to look for signs of an estrogen imbalance and potential underlying causes.
Estrogen lab test results could vary based on a man’s age, lifestyle, and the form of estrogen measured. Individuals might need to be tested more than once to look for estrogen level trends over time, as they typically fluctuate often. Providers use the results to determine the best next steps to achieving hormone balance and optimal health.
Treatment and Management Strategies
Several treatments and management strategies exist for estrogen imbalance in men. Examples include:
- Hormone replacement therapy (HRT)
- Medications (aromatase inhibitors)
- Weight management
- Dietary interventions
- Exercise
- Other healthy lifestyle habits
Ways to naturally balance estrogen in men include eating a well-balanced diet (including phytoestrogens to naturally increase estrogen in individuals with low estrogen), exercising most days of the week, getting enough sleep, and minimizing stress. Try relaxation techniques, including meditation, yoga, deep breathing, massage, or tai chi.
Examples of ways to decrease estrogen or optimize male hormone balance include:
- Decrease body fat with diet and exercise
- Limit the intake of processed sugar and alcohol
- Reduce exposure to xenoestrogens
Individuals can minimize xenoestrogen exposure by choosing whole, organic foods whenever possible and avoiding certain plastics and other potentially harmful endocrine disruptors.
[signup]
Key Takeaways
Estrogen is more than simply a “female hormone.” Recognizing the signs and symptoms of unbalanced estrogen in men is crucial, yet sometimes neglected by patients or providers. Estrogen balance is a vital component of men’s health, as it’s needed for proper sexual functioning and optimal brain, heart, bone, nervous system, skin, and muscle health.
Numerous factors may contribute to excess or insufficient estrogen production in men. Determining the potential causes, properly diagnosing hormone imbalance with lab testing, and treating it effectively are key.
Lab Tests in This Article
References
3 ways to increase estrogen naturally. (2023, June 2). www.uclahealth.org. https://www.uclahealth.org/news/3-ways-increase-estrogen-naturally
Anderson, S. (2022, July 22). 5 conditions that make it harder to lose weight. Rupa Health. https://www.rupahealth.com/post/cant-lose-weight-these-5-medical-problems-may-be-why
Chen, T., Wu, F., Wang, X., Ma, G., Xuan, X., Tang, R., Ding, S., & Lu, J. (2020). Different levels of estradiol are correlated with sexual dysfunction in adult men. Scientific Reports, 10(1), 12660. https://doi.org/10.1038/s41598-020-69712-6
Christie, J. (2022, March 25). The most common causes of infertility in men and women. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-infertility
Christie, J. (2023a, January 6). A functional medicine approach to obesity and weight management. Rupa Health. https://www.rupahealth.com/post/an-integrative-approach-to-obesity
Christie, J. (2023b, January 31). How to add bioidentical hormone replacement therapy to your integrative medicine clinic. Rupa Health. https://www.rupahealth.com/post/how-to-add-bioidentical-hormone-replacement-therapy-to-your-integrative-medicine-clinic
Christie, J. (2022b, June 9). 8 products that contain endocrine disrupting chemicals (and how to avoid them). Rupa Health. https://www.rupahealth.com/post/how-chemicals-are-effecting-our-hormones
Cleveland Clinic. (2022a, February 8). Low estrogen: Causes, symptoms, diagnosis & treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/22354-low-estrogen
Cleveland Clinic. (2022b, February 9). High estrogen: Causes, symptoms, dominance & treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/22363-high-estrogen
Cleveland Clinic. (2022c, August 2). Estrogen: Hormone, function, levels & imbalances. Cleveland Clinic; Cleveland Clinic. https://my.clevelandclinic.org/health/body/22353-estrogen
Cloyd, J. (2023a, April 7). Functional medicine high cholesterol protocol. Rupa Health. https://www.rupahealth.com/post/functional-medicine-high-cholesterol-protocol
Cloyd, J. (2023b, August 25). A root cause medicine protocol for patients with insomnia: Testing, therapeutic diet, and supportive supplements. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-protocol-for-patients-with-insomnia-testing-therapeutic-diet-and-supportive-supplements
Cloyd, J. (2023c, October 2). A functional medicine approach to stress management. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-stress-management
Cloyd, J. (2023d, December 1). A functional medicine protocol for balancing blood sugar. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-balancing-blood-sugar
Cloyd, J. (2024, February 28). The link between erectile dysfunction and cardiovascular disease: Understanding the connection. Rupa Health. https://www.rupahealth.com/post/the-link-between-erectile-dysfunction-and-cardiovascular-disease-understanding-the-connection
Cox, A. (2022, November 3). 5 science backed health benefits of collagen. Rupa Health. https://www.rupahealth.com/post/5-science-backed-health-benefits-of-collagen
Creedon, K. (2022, March 18). 8 ways to prevent osteoporosis as you age. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-osteoporosis
DeCesaris, L. (2023, December 12). Elevating mood with nutraceuticals: A functional medicine perspective. Rupa Health. https://www.rupahealth.com/post/elevating-mood-with-nutraceuticals-a-functional-medicine-perspective
Diorio, B. (2023, January 17). Why most functional medicine practitioners say no to alcohol. Rupa Health. https://www.rupahealth.com/post/why-most-functional-medicine-practitioners-say-no-to-alcohol
ESTF - overview: Estrogens, estrone (E1) and estradiol (E2), fractionated, serum. (2016). @Mayocliniclabs. https://www.mayocliniclabs.com/test-catalog/Overview/84230#Clinical-and-Interpretive
Easthope, A. (2022, April 26). 11 common causes of low male testosterone (and how to fix them). Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-low-male-testosterone-hypogonadism
Estradiol. (2024). Rupa Health. https://www.rupahealth.com/biomarkers/e2
Estriol. (2024). Rupa Health. https://www.rupahealth.com/biomarkers/estriol
Estrogen levels test: MedlinePlus lab test information. (2022, October 4). Medlineplus.gov. https://medlineplus.gov/lab-tests/estrogen-levels-test/
Estrogen: What it does and 5 benefits. (2022, January 4). Cleveland Clinic. https://health.clevelandclinic.org/what-does-estrogen-do
Estrogens, estrone (E1) and estradiol (E2), fractionated, serum - mayo clinic laboratories | pediatric catalog. (2016). Testcatalog.org. https://pediatric.testcatalog.org/show/ESTF
Estrone. (2024). Rupa Health. https://www.rupahealth.com/biomarkers/estrone
Khakham, C. (2023a, April 6). Understanding your risk of cardiovascular disease with functional medicine labs. Rupa Health. https://www.rupahealth.com/post/understanding-your-risk-of-cardiovascular-disease-with-functional-medicine-labs
Khakham, C. (2023c, August 4). Top labs to run bi-annually on your male low libido patients. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-male-low-libido-patients
Khakham, C. (2023b, June 30). Personalizing skin health: Leveraging functional medicine labs to tailor dietary interventions and supplements. Rupa Health. https://www.rupahealth.com/post/using-dietary-interventions-and-supplements-to-support-healthy-skin
LoBisco, S. (2022, November 16). 7 natural treatments for low progesterone. Rupa Health. https://www.rupahealth.com/post/progesterone-imbalance-signs-treatments
Maholy, N. (2023, April 24). A functional medicine protocol for hypo-responsiveness adrenal dysregulation. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-hypo-responsiveness-adrenal-dysregulation
Maholy, N. (2023a, April 14). How to reduce stress through mind-body therapies. Rupa Health. https://www.rupahealth.com/post/how-to-reduce-stress-through-mind-body-therapies
Orbeta, R. (2022, April 1). 8 signs and symptoms of an autoimmune disease. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-autoimmune-disease
Preston, J. (2023a, March 15). An integrative medicine approach to managing menopause symptoms. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-managing-menopause-symptoms
Preston, J. (2023b, September 13). A functional medicine protocol for fatigue: Lab testing, nutrition, and helpful supplements. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-fatigue-lab-testing-nutrition-and-helpful-supplements
Ramasamy, R., Schulster, M., & Bernie, A. (2016). The role of estradiol in male reproductive function. Asian Journal of Andrology, 18(3), 435. https://doi.org/10.4103/1008-682x.173932
Sweetnich, J. (2023, February 23). 4 functional medicine labs to test for root cause of estrone imbalance. Rupa Health. https://www.rupahealth.com/post/4-functional-medicine-labs-to-test-for-root-cause-of-estrone-imbalance
Teeter, L. A. (2023, May 10). Complementary and integrative medicine approaches to eating disorders. Rupa Health. https://www.rupahealth.com/post/complementary-and-integrative-medicine-approaches-to-eating-disorders
Varanasi-Diaz, S. (2024, April 1). Integrative approaches to enhanced focus and concentration. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-enhanced-focus-and-concentration
Weinberg, J. (2023, May 9). What are xenoestrogens and how to test for exposure. Rupa Health. https://www.rupahealth.com/post/what-are-xenoestrogens-and-how-you-can-avoid-them
Weinberg, J. (2024, January 11). Enhancing sleep quality during shorter days: Insights from functional medicine. Rupa Health. https://www.rupahealth.com/post/enhancing-sleep-quality-during-shorter-days-insights-from-functional-medicine
Yoshimura, H. (2023a, October 23). How to support your liver health with nutritional interventions in functional medicine. Rupa Health. https://www.rupahealth.com/post/nutritional-interventions-in-functional-medicine-for-liver-support
Yoshimura, H. (2023b, November 7). The remarkable power of exercise on our health: A comprehensive overview. Rupa Health. https://www.rupahealth.com/post/the-remarkable-power-of-exercise-on-our-health-a-comprehensive-overview
Yoshimura, H. (2023c, November 22). Nature’s sweet vs. factory’s treat: What’s the difference between natural sugars and added sugars? Rupa Health. https://www.rupahealth.com/post/natures-sweet-vs-factorys-treat-whats-the-difference-between-natural-sugars-and-added-sugars
Yoshimura, H. (2024, January 22). Functional medicine and hormone therapy in aging male populations. Rupa Health. https://www.rupahealth.com/post/functional-medicine-and-hormone-therapy-in-aging-male-populations