Menstrual cramps, a gynecological condition also known as dysmenorrhea, affects about 71.1% to 84.1% of young women and can have a substantial impact on their quality of life, affecting productivity, mood, and overall well-being. Oftentimes, women with dysmenorrhea experience other menstrual-related symptoms, including lumbosacral back pain, headaches, diarrhea, bloating, nausea, eye floaters, and even vomiting.
While conventional approaches to managing menstrual cramps typically focus on symptom relief, a functional medicine approach offers a more comprehensive and individualized strategy. This approach seeks to identify and address the root causes of menstrual cramps, integrating lifestyle practices, nutritional interventions, stress management, physical bodywork, acupuncture, and other targeted therapies to provide lasting relief and improve overall menstrual health and well-being.
[signup]
What Causes Menstrual Cramps?
Menstrual cramps are characterized by throbbing or cramping pain and discomfort in the lower abdomen or pelvic area. These pains typically occur just before and during menstrual periods and can range from mild to severe, sometimes interfering with daily activities. In addition to abdominal discomfort, symptoms may include pain that radiates to the lower back and thighs, nausea, loose stools, headache, sleep difficulty, and dizziness.
From a functional medicine perspective, menstrual cramps can stem from various underlying factors, including hormonal imbalances, inflammation, and nutritional deficiencies. Hormone-like substances called prostaglandins, involved in pain and inflammation, trigger the uterine muscle contractions that cause menstrual cramps. Higher levels of prostaglandins are associated with more severe cramps. Conditions such as endometriosis or uterine fibroids can also cause or exacerbate menstrual cramps.
Conventional treatments typically involve pain medications like NSAIDs, often over the counter, and hormonal interventions like birth control pills.
However, understanding the potential underlying causes of menstrual cramps is essential for developing effective management strategies that go beyond temporary symptom relief while avoiding further complications of chronic pain medications or synthetic hormones. By addressing these root causes, which may stem from hormonal imbalances, inflammation, or even dietary factors, functional medicine offers a more comprehensive and individualized approach to alleviating menstrual cramps and improving overall well-being.
Role of Hormonal Balance in Menstrual Cramps
There’s an intricate and tightly regulated interplay between hormones throughout the menstrual cycle that plays an important role in regulating smooth muscle contractions of the uterus and is responsible for menstrual cramps. Hormonal imbalances, particularly involving estrogen and progesterone, play a significant role in the development of menstrual cramps.
Although the connection between sex hormones and pain is complex, these imbalances lead to an overproduction of hormone-like substances called prostaglandins, which are cytokines involved in pain and inflammation. Higher levels of prostaglandins are associated with more severe cramps. Estrogen, a hormone that fluctuates throughout the menstrual cycle, can influence the intensity of menstrual cramps and pain sensitivity. During the menstrual cycle, estrogen levels rise and fall, and it is believed that excessive levels of estrogen lead to an increase in inflammatory prostaglandin production, resulting in more intense cramping.
Elevated prostaglandins cause narrowing of the blood vessels to the uterus, which leads to poor circulation, decreased oxygenation (hypoxia) of the uterus, and increased sensitivity of the nerve endings.
Progesterone, a key hormone during the luteal phase of the menstrual cycle, plays a role in the development of cramps by helping to control prostaglandin production. Lower levels of progesterone also contribute to an increase in prostaglandin production, thus contributing to more severe cramping.
Progesterone is well known to be a smooth muscle relaxant, anxiolytic, analgesic, and sedative with its GABAergic actions on the central nervous system (brain, spinal cord), and thus is likely to reduce menstrual pain. Functional medicine testing with specialty labs aims to identify relative estrogen to progesterone balance and address these hormonal imbalances with more detailed urine and saliva hormone testing.
Functional Medicine Testing to Assess Menstrual Cramps
Functional medicine testing plays a pivotal role in identifying the exact underlying causes of menstrual discomfort accurately, such as hormonal imbalances, inflammation, or nutritional deficiencies. This approach involves a comprehensive assessment to understand the unique physiological factors contributing to an individual's experience of dysmenorrhea. Tests like hormone panels, micronutrient testing, and inflammatory markers are instrumental in guiding personalized treatment approaches for more targeted and effective treatment strategies with precision and accuracy. There’s a greater chance of markedly better outcomes than generalized approaches.
DUTCH Plus or DUTCH Cycle Mapping Plus
Hormone panels, such as the DUTCH Plus or DUTCH Cycle Mapping Plus test, evaluate sex hormone metabolites, including estrogen and progesterone, throughout the menstrual cycle. This information is valuable in identifying hormonal imbalances that may contribute to menstrual cramps. Additionally, these tests assess other steroid hormones, including the stress hormone cortisol, providing insights into potential stress-related factors influencing painful periods.
Micronutrient Testing
Micronutrient testing, such as the Micronutrient Test by SpectraCell Laboratories, helps determine whether important intracellular vitamins, minerals, antioxidants, and essential fatty acid deficiencies are contributing to dysmenorrhea. This information is useful to help guide dietary and supplement dosing recommendations to replete any identified vitamin and mineral deficiencies.
The liver requires specific nutrients to help detoxify and clear excess estrogen metabolites out of the body to maintain a balance between estrogen and progesterone. Some important nutrients to assess are magnesium, folate, B12, vitamin E, zinc, selenium, cysteine, choline, inositol, serine, and omega-3 fatty acids.
hs-CRP Inflammatory Marker
Inflammatory markers are also assessed to understand the role of inflammation in menstrual cramps. One such marker, high sensitivity C-reactive protein (hs-CRP), is particularly noteworthy due to its association with systemic inflammation and has been found to have connections not just to overall health but specifically to cardiovascular and reproductive organ health, including the uterus.
By utilizing these tests, practitioners can develop personalized treatment plans that address the specific imbalances, excesses, or deficiencies contributing to menstrual cramps, ultimately offering not just temporary alleviation but potentially complete resolution over time.
[signup]
Dietary Management for Menstrual Cramps
Diet can be a powerful ally for the impact it has daily. The right food choices not only soothe the pain but also can actively work towards easing those monthly bouts. Eating anti-inflammatory foods rich in antioxidants will calm inflammation and reduce muscle spasms, which will tame the cramp intensity.
Understanding which nutrients are our allies is important. Hands down, magnesium is front and center for its muscle-relaxant action to directly target uterine contractions, bringing much-needed relief. Look no further than dark leafy greens, cruciferous vegetables, nuts, and seeds to up your magnesium intake. Omega-3 fatty acids found in fish such as salmon and sardines, and seeds such as flax, hemp, and chia seeds serve double duty by fighting inflammation while simultaneously curbing the production of those inflammatory prostaglandins responsible for painful cramps.
B vitamins, particularly Vitamin B1 (thiamine) and B6 (pyridoxine), are essential for energy metabolism and neuromuscular function – both critical during periods of menstrual distress.
However, what you avoid is just as much part of the victory. Excessive caffeine, sugar, processed meats, and processed junk foods are notorious triggers exacerbating menstrual discomfort through increased constriction of blood vessels and bloating—these are best kept off the menu during your cycle.
Incorporating these principles into nutrition for dysmenorrhea offers an empowering approach to managing menstrual cramps through dietary choices. By dialing down on inflammatory foods while saturating your system with nourishing minerals like magnesium, alongside Omega-3s & rich sources of B vitamins -- women everywhere are reclaiming relief and comfort one meal at a time.
Stress Reduction and Its Impact on Menstrual Cramps
Stress reduction undeniably factors in for managing and alleviating menstrual cramps. There’s a positive relationship between the severity of psychological stress and the severity of dysmenorrhea. So, reducing stress levels can reduce the severity of menstrual cramps. When the body perceives stress, is in a stressed state, or stressful situation, there’s a physiological response by the body to stress where the body releases cortisol. This excess state of cortisol can lead to increased inflammation and pain sensitivity and exacerbate menstrual cramps.
Implementing various stress reduction techniques can be helpful here. These may include deep breathing, meditation, yoga, and walking out in nature. Additionally, acupuncture and acupressure might help alleviate menstrual cramps by reducing stress and promoting relaxation.
Meditation with mindfulness is an effective method to reduce overall stress levels and lessen the intensity of menstrual cramps by promoting relaxation and reducing cortisol levels.
Yoga is another beneficial practice for stress reduction for menstrual cramps. It combines physical postures and stretching with breathing exercises to relieve tension throughout the body, including areas affected during menstruation. Yoga not only aids in relaxation but also improves blood circulation to the pelvic region, which may potentially diminish the severity of cramps.
Deep breathing exercises are equally important in managing dysmenorrhea with relaxation. Deep breaths help activate the parasympathetic nervous system—the part responsible for calming bodily functions—thus reducing stress-induced exacerbation of menstrual symptoms. An easy add to this would be diffusing relaxing essential oils like lavender and clary sage into the air.
Incorporating stress reduction lifestyle practices into your routine, including adequate quality sleep, offers a natural approach to mitigating menstrual discomfort through stress management and non-pharmacological means for relief.
Physical Activity and Menstrual Cramps
Regular physical activity can significantly alleviate menstrual cramps so they are more manageable. Specifically, exercise for menstrual cramps emerges as not just a remedy but a preventive strategy that enhances a woman’s overall menstrual health.
Women who exercise regularly have fewer menstrual cramps.
A simple search will find a plethora of different types of exercises available, and the intensity and type of exercise are tailored to comfort levels during heavy menstruation. In general, gentler, low-impact activities stand out for their effectiveness in reducing the severity of cramps, particularly if the pain is severe.
Yoga and Tai Chi, for instance, can help relax muscles and ease tension throughout the body. Choose poses that stretch the core, lower back, and hips for relief.
Even moderate to short bouts of intense physical activity, like functional fitness exercises, can have a positive effect on reducing menstrual pain and discomfort. This will help bring more circulation to the pelvic region and break up some of the stagnation often associated with pain. Walking at a brisk pace is another excellent form of physical activity and dysmenorrhea management. Consider Pilates movements that are controlled and focus on core strength, which indirectly supports the pelvic area during menstruation.
Women who participate in regular exercise of 45-60 minutes three times per week, regardless of intensity, report less pain during menstruation compared to sedentary women.
Incorporating physical activity into your routine, especially low-impact exercises before or during your period, can help provide relief without needing to reach for pain medications. Exercise naturally releases pain-relieving endorphins and helps with reducing inflammation while cramping.
Complementary and Integrative Therapies
Women seem to be exceedingly exploring complementary and integrative therapies for managing menstrual cramps. Notably, treatments such as herbal remedies, acupuncture, acupressure, TENS units, and heat therapies like castor oil packs and moxibustion are emerging as effective alternative therapies for menstrual cramps.
Acupuncture, rooted in traditional Southeast Asian medicines, involves fine needles being inserted at specific body points to stimulate qi, energy, blood circulation, the release of endogenous pain-relieving endorphins, and calm the nervous system. Various studies on this highlight the role acupuncture has in significantly reducing both the severity and duration of menstrual cramps.
Moxibustion, or “moxa” for short, is a warming adjunctive treatment within various acupuncture styles, especially heavily used within Japanese acupuncture. It’s the use of warming an herb mugwort to bring qi, blood, and tonification to a region or specific acupuncture point. Moxa is a more effective analgesic than NSAIDs for dysmenorrhea. The mechanism for analgesia relates to modulating brain activity for pain – specifically around disorders of the reappraisal and processing of pain stimuli.
Herbal remedies have long-standing use as a solution within complementary treatments for dysmenorrhea, and contemporary research validates these practices. Herbs like ginger, fennel, cramp bark, and passionflower have traditionally been used to alleviate pain. Passionflower has GABAergic, spasmolytic, anxiolytic, and anti-inflammatory actions. Interestingly, the combination of fennel with aerobic exercise was found to be beneficial in reducing the severity of dysmenorrhea and other premenstrual symptoms that often accompany it.
While evidence backs many of these integrative approaches' efficacy in managing menstrual cramps, it's crucial to consult healthcare professionals like Naturopathic Doctors for professional guidance before initiating any new treatment plan.
[signup]
Key Takeaways
Adopting a functional medicine approach to managing menstrual cramps underscores the importance of holistic and individualized treatments. This perspective not only acknowledges but addresses the complex interplay between various factors contributing to menstrual discomfort.
By encouraging a multifaceted strategy that includes dietary adjustments, lifestyle modifications, complementary therapies, and specialized functional medicine testing, individuals can access comprehensive care tailored specifically to their needs.
Embracing this holistic approach to managing menstrual cramps promises not just symptomatic relief but also long-term wellness and improved quality of life. It's an empowering journey towards understanding and nurturing one's body in its entirety.
Lab Tests in This Article
References
- Armour, M., Smith, C. A., Steel, K. A., & Macmillan, F. (2019). The effectiveness of self-care and lifestyle interventions in primary dysmenorrhea: a systematic review and meta-analysis. BMC Complementary and Alternative Medicine, 19(1). https://doi.org/10.1186/s12906-019-2433-8(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337810/ )
- https://www.webmd.com/women/menstrual-cramps. (2017, April 21). What Are Menstrual Cramps? WebMD; WebMD. https://www.webmd.com/women/menstrual-cramps
- Mayo Clinic. (2018). Menstrual cramps - Symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/menstrual-cramps/symptoms-causes/syc-20374938
- Cleveland Clinic. (2020, November 20). What Is Dysmenorrhea / Menstrual Cramps | Cleveland Clinic: Health Library. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/4148-dysmenorrhea
- Mayo Clinic. (2018a). Menstrual cramps - Diagnosis and treatment - Mayo Clinic. Mayoclinic.org. https://www.mayoclinic.org/diseases-conditions/menstrual-cramps/diagnosis-treatment/drc-20374944
- Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. Obstet Gynecol. 2006;108(2):428–441. doi: 10.1097/01.AOG.0000230214.26638.0c.
- Barcikowska, Z., Rajkowska-Labon, E., Grzybowska, M. E., Hansdorfer-Korzon, R., & Zorena, K. (2020). Inflammatory Markers in Dysmenorrhea and Therapeutic Options. International journal of environmental research and public health, 17(4), 1191. https://doi.org/10.3390/ijerph17041191(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068519/ )
- Dawood, M. Y., Gold, J. J., & Josimovich, J. B. (1987). Gynecologic endocrinology.
- Vincent, K., & Tracey, I. (2008). Hormones and their Interaction with the Pain Experience. Reviews in pain, 2(2), 20–24. https://doi.org/10.1177/204946370800200206(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589942/ )
- Maholy, N. (2023, March 2). A Functional Medicine Protocol for Dysmenorrhea. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-dysmenorrhea
- Barcikowska, Z., Rajkowska-Labon, E., Grzybowska, M. E., Hansdorfer-Korzon, R., & Zorena, K. (2020). Inflammatory Markers in Dysmenorrhea and Therapeutic Options. International journal of environmental research and public health, 17(4), 1191. https://doi.org/10.3390/ijerph17041191(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068519/ )
- How to Interpret Your CRP Blood Test. (2023, December 11). Rupa Health. https://www.rupahealth.com/post/how-to-interpret-your-crp-blood-test
- Shin, H. J., Na, H. S., & Do, S. H. (2020). Magnesium and Pain. Nutrients, 12(8), 2184. https://doi.org/10.3390/nu12082184(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468697/ )
- Saei Ghare Naz, M., Kiani, Z., Rashidi Fakari, F., Ghasemi, V., Abed, M., & Ozgoli, G. (2020). The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta-Analysis. Journal of caring sciences, 9(1), 47–56. https://doi.org/10.34172/jcs.2020.008(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146731/ )
- Rahbar, N., Asgharzadeh, N., & Ghorbani, R. (2012). Effect of omega-3 fatty acids on intensity of primary dysmenorrhea. International Journal of Gynecology & Obstetrics, 117(1), 45–47. https://doi.org/10.1016/j.ijgo.2011.11.019(link: https://www.sciencedirect.com/science/article/abs/pii/S0020729211006564 )
- Najafi, N., Khalkhali, H., Moghaddam Tabrizi, F., & Zarrin, R. (2018). Major dietary patterns in relation to menstrual pain: a nested case control study. BMC women's health, 18(1), 69. https://doi.org/10.1186/s12905-018-0558-4
- Ciołek, A., Kostecka, M., Kostecka, J., Kawecka, P., & Popik-Samborska, M. (2023). An Assessment of Women's Knowledge of the Menstrual Cycle and the Influence of Diet and Adherence to Dietary Patterns on the Alleviation or Exacerbation of Menstrual Distress. Nutrients, 16(1), 69. https://doi.org/10.3390/nu16010069
- Maryam, et al. “Relationship between Menstrual Profile and Psychological Stress with Dysmenorrhea.” Althea Medical Journal, vol. 3, no. 3, Sept. 2016, pp. 382–387, https://doi.org/10.15850/amj.v3n3.884. Accessed 19 Mar. 2020.
- “Menstrual Cramps - Diagnosis and Treatment - Mayo Clinic.” Mayoclinic.org, 2018, www.mayoclinic.org/diseases-conditions/menstrual-cramps/diagnosis-treatment/drc-20374944.
- Physical activity and your menstrual cycle | Office on Women’s Health. (n.d.). Www.womenshealth.gov. https://www.womenshealth.gov/getting-active/physical-activity-menstrual-cycle#references
- Daley, A. (2009). The role of exercise in the treatment of menstrual disorders: the evidence. British Journal of General Practice, 59(561), 241–242. https://doi.org/10.3399/bjgp09x420301(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662100/ )
- Hightower, M. (1998). Effects of Exercise Participation on Menstrual Pain and Symptoms. Women & Health, 26(4), 15–27. https://doi.org/10.1300/j013v26n04_02(link: https://pubmed.ncbi.nlm.nih.gov/9525266/ )
- Guo, Y., Liu, F. Y., Shen, Y., Xu, J. Y., Xie, L. Z., Li, S. Y., Ding, D. N., Zhang, D. Q., & Han, F. J. (2021). Complementary and Alternative Medicine for Dysmenorrhea Caused by Endometriosis: A Review of Utilization and Mechanism. Evidence-based complementary and alternative medicine : eCAM, 2021, 6663602. https://doi.org/10.1155/2021/6663602(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272670/ )
- Zhang, F., Sun, M., Han, S., Shen, X., Luo, Y., Zhong, D., Zhou, X., Liang, F., & Jin, R. (2018). Acupuncture for Primary Dysmenorrhea: An Overview of Systematic Reviews. Evidence-based complementary and alternative medicine : eCAM, 2018, 8791538. https://doi.org/10.1155/2018/8791538(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280308/ )
- Iorno, V., Burani, R., Bianchini, B., Minelli, E., Martinelli, F., & Ciatto, S. (2008). Acupuncture Treatment of Dysmenorrhea Resistant to Conventional Medical Treatment. Evidence-Based Complementary and Alternative Medicine, 5(2), 227–230. https://doi.org/10.1093/ecam/nem020(link: https://atriumhealth.org/documents/northeastinternalintegrative/research-library/obgyn/dysmenorrhearesistant.pdf )
- Abubakar, U., Zulkarnain, A. I., Samri, F., Hisham, S. R., Alias, A., Ishak, M., Sugiman, H., & Ghozali, T. (2020). Use of complementary and alternative therapies for the treatment of dysmenorrhea among undergraduate pharmacy students in Malaysia: a cross sectional study. BMC complementary medicine and therapies, 20(1), 285. https://doi.org/10.1186/s12906-020-03082-4(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501717/ )
- Yang, H., Li, X., Guo, X. L., Zhou, J., Shen, Z. F., Liu, L. Y., Wei, W., Yang, L., Yu, Z., Chen, J., Liang, F. R., Yu, S. Y., & Yang, J. (2022). Moxibustion for primary dysmenorrhea: A resting-state functional magnetic resonance imaging study exploring the alteration of functional connectivity strength and functional connectivity. Frontiers in neuroscience, 16, 969064. https://doi.org/10.3389/fnins.2022.969064(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469737/ )
- Kim, M., Lim, H. S., Lee, H. H., & Kim, T. H. (2017). Role Identification of Passiflora Incarnata Linnaeus: A Mini Review. Journal of menopausal medicine, 23(3), 156–159. https://doi.org/10.6118/jmm.2017.23.3.156(link: https://pubmed.ncbi.nlm.nih.gov/29354614/ )
- Kong X, Fang H, Li X, Zhang Y, Guo Y. Effects of auricular acupressure on dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials. Front Endocrinol (Lausanne). 2023 Jan 5;13:1016222. doi: 10.3389/fendo.2022.1016222. PMID: 36686444; PMCID: PMC9851274.(link: https://pubmed.ncbi.nlm.nih.gov/36686444/ )
- Gurung, A., Khatiwada, B., Kayastha, B., Parsekar, S., Mistry, S. K., & Yadav, U. N. (2022). Effectiveness of Zingiber Officinale(ginger) compared with non-steroidal anti-inflammatory drugs and complementary therapy in primary dysmenorrhoea: A systematic review. Clinical Epidemiology and Global Health, 18, 101152. https://doi.org/10.1016/j.cegh.2022.101152(link: https://www.sciencedirect.com/science/article/pii/S2213398422001944 )
- Pazoki, H., Bolouri, G., Farokhi, F., & Azerbayjani, M. A. (2016). Comparing the effects of aerobic exercise and Foeniculum vulgare on pre-menstrual syndrome. Middle East Fertility Society Journal, 21(1), 61–64. https://doi.org/10.1016/j.mefs.2015.08.002(link: https://www.sciencedirect.com/science/article/pii/S1110569015200659 )
- Goel, B., & Maurya, N. K. (2019). Overview on: Herbs Use in Treatment of Primary Dysmenorrhea (Menstrual Cramps). Advances in Zoology and Botany, 7(3), 47–52. https://doi.org/10.13189/azb.2019.070302(link: https://www.researchgate.net/publication/338112971_Overview_on_Herbs_Use_in_Treatment_of_Primary_Dysmenorrhea_Menstrual_Cramps )
- Tork, H., F Mojab, M Akhavan Amjadi, & Alavi Majd Hamid. (2007). CLINICAL EFFECTS OF FOENICULUM VULGARE EXTRACT ON PRIMARY DYSMENORRHEAL. JOURNAL of REPRODUCTION and INFERTILITY, 8(130), 45–51.(link: https://www.proquest.com/openview/e544a719bf9298c1e9d865e43da06ca7/1?pq-origsite=gscholar&cbl=105706 )
- Ristiani, Arsyad, A., Usman, A. N., Syamsuddin, S., Ahmad, M., & Sinrang, A. W. (2021). The use of aromatherapy in primary dysmenorrhea. Gaceta Sanitaria, 35, S591–S595. https://doi.org/10.1016/j.gaceta.2021.10.090(link: https://www.sciencedirect.com/science/article/pii/S0213911121002946)
- Jiao, M., Liu, X., Ren, Y., Wang, Y., Cheng, L., Liang, Y., Li, Y., Zhang, T., Wang, W., & Mei, Z. (2022). Comparison of Herbal Medicines Used for Women’s Menstruation Diseases in Different Areas of the World. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.751207(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854496/ )
- Trayambak, D., Gomathy, N., Dhanasekar, K., & Amirtha, R. (2019). Supportive therapy for dysmenorrhea: Time to look beyond mefenamic acid in primary care. Journal of Family Medicine and Primary Care, 8(11),
- https://doi.org/10.4103/jfmpc.jfmpc_717_19(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881953/
- Armour, M., Ee, C. C., Naidoo, D., Ayati, Z., Chalmers, K. J., Steel, K. A., de Manincor, M. J., & Delshad, E. (2019). Exercise for dysmenorrhoea. Cochrane Database of Systematic Reviews, 9. https://doi.org/10.1002/14651858.cd004142.pub4(link: https://pubmed.ncbi.nlm.nih.gov/31538328/ )
- Nagy, H., & Khan, M. A. (2020). Dysmenorrhea. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK560834/(link: https://www.ncbi.nlm.nih.gov/books/NBK560834/ )
- Yoshimura, H. (2023, July 17). Using Functional Medicine As Personalized Medicine. Rupa Health. https://www.rupahealth.com/post/using-functional-medicine-as-personalized-medicine
- Schoep, M. E., Nieboer, T. E., van der Zanden, M., Braat, D. D. M., & Nap, A. W. (2019). The impact of menstrual symptoms on everyday life: a survey among 42,879 women. American Journal of Obstetrics and Gynecology, 220(6), 569.e1–569.e7. https://doi.org/10.1016/j.ajog.2019.02.048(link: https://pubmed.ncbi.nlm.nih.gov/30885768/ )
- Fajrin, I., Alam, G., & Usman, A. N. (2020). Prostaglandin level of primary dysmenorrhea pain sufferers. Enfermería Clínica, 30, 5–9. https://doi.org/10.1016/j.enfcli.2019.07.016(link: https://www.sciencedirect.com/science/article/abs/pii/S1130862119303158 )
- MacLean, J. A., & Hayashi, K. (2022). Progesterone Actions and Resistance in Gynecological Disorders. Cells, 11(4), 647. https://doi.org/10.3390/cells11040647(link: https://pubmed.ncbi.nlm.nih.gov/35203298/ )
- Bernardi, M., Lazzeri, L., Perelli, F., Reis, F. M., & Petraglia, F. (2017). Dysmenorrhea and related disorders. F1000Research, 6(6), 1645. https://doi.org/10.12688/f1000research.11682.1(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585876/#ref-24 )
- Song, B., & Kim, J. (2023). Effects of Pilates on Pain, Physical Function, Sleep Quality, and Psychological Factors in Young Women with Dysmenorrhea: A Preliminary Randomized Controlled Study. Healthcare, 11(14), 2076–2076. https://doi.org/10.3390/healthcare11142076(link: https://pubmed.ncbi.nlm.nih.gov/37510517/ )
- Armour, M., Parry, K., Manohar, N., Holmes, K., Ferfolja, T., Curry, C., MacMillan, F., & Smith, C. A. (2019). The Prevalence and Academic Impact of Dysmenorrhea in 21,573 Young Women: A Systematic Review and Meta-Analysis. Journal of Women’s Health, 28(8), 1161–1171. https://doi.org/10.1089/jwh.2018.7615(link: https://pubmed.ncbi.nlm.nih.gov/31170024/ )
- Grandi, G., Ferrari, S., Xholli, A., Cannoletta, M., Palma, F., Volpe, A., Cagnacci, A., & Romani, C. (2012). Prevalence of menstrual pain in young women: what is dysmenorrhea? Journal of Pain Research, 5, 169. https://doi.org/10.2147/jpr.s30602(link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392715/ )
- Mishra Sp, & Singh Rh. (1984). Effect of certain yogic asanas on the pelvic congestion and it’s anatomy. Ancient Science of Life, 4(2), 127–128. https://www.researchgate.net/publication/224898702_Effect_of_certain_yogic_asanas_on_the_pelvic_congestion_and_it's_anatomy(link: https://www.researchgate.net/publication/224898702_Effect_of_certain_yogic_asanas_on_the_pelvic_congestion_and_it's_anatomy )