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Reference Guide
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rT3
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Reverse Triiodothyronine

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What's 
rT3
?
Reverse Triiodothyronine (rT3) is a special hormone created by your thyroid gland, a small yet powerful organ located in your neck. It's formed during the process of converting the thyroid hormone T4 into the active hormone T3. Although rT3 might seem like a minor character, it has a vital role in your body's complex hormone balance. It works as a natural control system, slowing down your metabolism when your body experiences stress, saving energy for when it's most necessary. This makes rT3 a key part of your body's stress response, helping to keep a delicate balance in how your body manages energy.
If Your Levels Are High
Elevated rT3 levels might mean that your body is trying to save energy because it senses stress. This can happen for various reasons, such as long-term illness, intense dieting, high physical or emotional stress, or even specific medications like beta-blockers or steroids. It's like your body is pressing the 'pause' button on your metabolism to make sure you have enough energy to handle the situation. High rT3 levels could also suggest a problem with how your body changes T4 into T3, the active thyroid hormone. While rT3 is a normal and important part of how your body reacts to stress, constantly high levels might interfere with your body's energy balance and overall metabolic function.
Symptoms of High Levels
Symptoms of high levels of rT3 could include fatigue, weight gain, depression, cold intolerance, and cognitive difficulties such as poor focus and memory issues.
If Your Levels are Low
Low rT3 levels might mean that your body's natural system for controlling metabolism isn't working properly. This could be due to several reasons, such as not having enough building blocks like iodine or selenium to make rT3, or a problem with the process of changing T4 into T3. Some medications, like beta blockers or steroids, could also affect rT3 production. Possible underlying causes for low rT3 levels include ongoing stress, tired adrenal glands, or problems with your liver or kidneys, since these organs are important for hormone conversion.
Symptoms of Low Levels
Symptoms of low levels of rT3 may include unexplained weight loss, increased heart rate, anxiety, irritability, difficulty sleeping, and feeling unusually warm.

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Reverse Triiodothyronine

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